Abstract:Knee osteoarthritis（KOA）has become one of the significant diseases causing disability and chronic pain worldwide in recent years, seriously affecting human health. As the main manifestation of KOA, pain often persists throughout the entire pathological process of the disease and seriously affects the prognosis of the disease. Research on the pain mechanism of KOA focuses on local inflammatory responses, pain sensitization, angiogenesis and tissue remodeling. Surgical treatment for KOA is limited by multiple indications, resulting in low postoperative patients’ satisfaction and persistent symptoms. This article reviews the mechanisms of development of KOA pain, Chinese medicine therapy and modern rehabilitation Methods for treating KOA pain, exploring the influence of different treatment Methods on the development and progression of KOA pain, and providing evidence-based support for the clinical application of Chinese medicine therapy and modern rehabilitation Methods in treating KOA pain.