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投稿时间：2025-07-22 网络发布日期：2026-05-01
投稿时间：2025-07-22 网络发布日期：2026-05-01
中文摘要: 目的 探讨溃疡性结肠炎（UC）病灶组织中信号转导与转录激活因子（STAT）、细胞因子信号抑制因子（SOCS）的表达，分析其与UC严重程度及治疗结局的关系。方法 采用病例对照研究方案，选取沧州市人民医院确诊的70例UC患者作为UC组，既往因外伤、手术等原因获取的70例经病理学检查证实为正常肠黏膜组织作为对照组，对比两组肠黏膜组织中STAT mRNA、SOCS mRNA相对表达量，并根据疾病处于活动期（n=55）和缓解期（n=15）进行分层，对活动期UC患者实施美沙拉秦治疗，对比不同疗效患者的STAT mRNA、SOCS mRNA相对表达量。结果 UC 组肠黏膜STAT1、STAT3、STAT5 mRNA 相对表达量均高于对照组，SOCS2、SOCS3 mRNA相对表达量均低于对照组，差异有统计学意义（P<0.05）。活动期UC患者的肠黏膜STAT5 mRNA相对表达量高于缓解期患者（P<0.05），SOCS2、SOCS3 mRNA相对表达量均低于缓解期UC患者（P<0.05）。55例活动期UC患者接受美沙拉秦治疗，疗效良好 38 例，疗效不佳 17 例。疗效不佳的活动期 UC 患者 STAT1、STAT3、STAT5mRNA 相对表达量均高于疗效良好UC 患者（P<0.05），SOCS2、SOCS3 mRNA 相对表达量均低于疗效良好的UC患者，差异有统计学意义（P<0.05）。结论 UC 病灶组织中 STAT1、STAT3、STAT5 mRNA 表达高于健康人群，SOCS2、SOCS3 mRNA表达低于健康人群，并且与疾病活动情况及治疗效果有关。
中文关键词: 溃疡性结肠炎 信号转导子与转录激活因子 细胞因子信号抑制子 疾病严重程度 治疗结局
Abstract:Objective To investigate the expression of signal transducer and activator of transcription（STAT）and suppressor of cytokine signaling（SOCS）in ulcerative colitis（UC）lesion tissue，and to analyze their relationship with the severity of UC and therapeutic outcomes. Methods A case-control study design was used，and 70 UC patients admitted to Cangzhou People's Hospital were selected as the UC group. Another 70 cases of normal intestinal mucosaltissue confirmed by pathological examination due to previous trauma，surgery，or other reasons were used as the control group. The expression levels of STAT mRNA and SOCS mRNA in the intestinal mucosal tissues of the two groups werecompared. Stratification was conducted based on disease in the active phase（n=55）or in remission phase（n=15）. Mesalazine treatment was administered to UC patients in active phase，and the STAT mRNA and SOCS mRNA expression levels were compared among patients with different treatment responses. Results The mRNA expression levels of STAT1，STAT3，and STAT5 in the intestinal mucosa of the UC group，were higher than those of the controlgroup，while the mRNA expression levels of SOCS2 and SOCS3 were lower than those of the control group，with thedifferences being statistically significant（P<0.05）. Compared with patients in remission phase，UC patients in active phase had significantly higher mRNA expression levels of STAT5 in intestinal mucosal（P<0.05），while significantly lower mRNA expression levels of SOCS2 and SOCS3（P<0.05）. Fifty-five UC patients in the active phase were treated with mesalazine，with 38 cases of good curative effect and 17 cases of poor curative effect. Compared with UC patients with good curative effects，UC patients with poor curative effects had higher expression levels of STAT1，STAT3 andSTAT5 mRNA（P<0.05），and lower expression levels of SOCS2 and SOCS3 mRNA（P<0.05）. Conclusion The mRNA expressions of STAT1，STAT3 and STAT5 in UC lesions are higher than those in healthy individuals，while the mRNA expressions of SOCS2 and SOCS3 are lower than those in healthy individuals，which are related to disease activity and treatment efficacy.
keywords: Ulcerative colitis Signal transducer and activator of transcription Suppressor of cytokine signaling Severity of disease Treatment outcome
文章编号： 中图分类号：R574.62 文献标志码：A
基金项目:沧州市科技计划项目（222106103）
附件
| Author Name | Affiliation |
| WANG Shujiao，LI Hongmei，XUE Zhimin，ZHAO Fengjuan，JIANG Xiaojia，SONG Shuli | Department of Gastroenterology,Cangzhou People's Hospital,Cangzhou,Hebei 061000,China |
引用文本：
王淑娇， 李红梅， 薛芝敏， 赵凤娟， 姜晓佳， 宋淑莉.溃疡性结肠炎患者肠黏膜组织中STAT、SOCS表达水平与疾病严重程度及预后的关系[J].中国临床研究,2026,39(4):522-526.
王淑娇， 李红梅， 薛芝敏， 赵凤娟， 姜晓佳， 宋淑莉.溃疡性结肠炎患者肠黏膜组织中STAT、SOCS表达水平与疾病严重程度及预后的关系[J].中国临床研究,2026,39(4):522-526.