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投稿时间：2025-02-11 网络发布日期：2026-01-27
投稿时间：2025-02-11 网络发布日期：2026-01-27
中文摘要: 目的 探讨急性胰腺炎（AP）患者血清S100钙结合蛋白（S100）A6、S100A9和S100A12水平，及该三项血清指标对重症急性胰腺炎（SAP）患者预后的预测价值。方法 前瞻性选择南京医科大学第四附属医院2022年5月至2024年5月收治的SAP患者60例为重症组，另选取同时段收治的60例轻症AP和中度SAP患者为非重症组。比较两组患者入院时的病情严重程度评分［急性胰腺炎严重程度床边指数（BISAP）评分、急性生理功能和慢性健康状况评分系统Ⅱ（APACHE Ⅱ）评分］及血清S100A6、S100A9和S100A12水平，分析重症组患者入院时血清指标水平与病情严重程度评分的相关性。重症组患者随访3个月后，根据患者的预后分为死亡亚组和生存亚组，比较两亚组患者入院时的血清三指标水平，并采用受试者工作特征（ROC）曲线分析入院时血清水平检测对SAP患者预后的预测价值。结果 重症组患者入院时的BISAP评分、APACHE Ⅱ评分、血清S100A6、S100A9和S100A12水平均显著高于非重症组，差异有统计学意义（P<0.01）。Pearson相关性分析结果显示，重症组患者入院时的血清 S100A6、S100A9 和 S100A12 水平与 APACHE Ⅱ评分分别呈正相关（r=0.710、0.880、0.860，P<0.01），Sl00A6和BISAP评正呈正相关（r=0.260，P<0.05）。死亡亚组入院时该三项血清指标水平均显著高于生存亚组（P<0.01）。ROC曲线分析结果显示，入院时血清S100A6、S100A9和S100A12水平检测预测SAP患者死亡的曲线下面积（AUC）分别为0.870、0.904和0.915。结论 SAP患者入院时血清S100A6、S100A9和S100A12水平显著升高，与病情严重程度密切相关，且入院时的血清水平对SAP患者预后具有较高的预测效能。
Abstract:Objective To investigate the levels of serum S100 calcium-binding proteins（S100）A6，S100A9，andS100A12 in patients with acute pancreatitis（AP），and to explore the prognostic value of these serum markers for severe acute pancreatitis（SAP）patients. Methods A total of 60 patients with SAP admitted to the Fourth Affiliated Hospital ofNanjing Medical University from May 2022 to May 2024 were prospectively selected as the severe group，while another 60mild AP and moderately SAP patients admitted during the same period were selected as the non-severe group. The severity scores at admission，including the Bedside Index for Severity in Acute Pancreatitis（BISAP），Acute Physiology and Chronic Health Evaluation Ⅱ（APACHE Ⅱ）score，and the levels of serum S100A6，S100A9，and S100A12 were compared between the two groups. The correlation between serum markers and severity scores was analyzed in the severe group. After three months of follow-up after，patients in the severe group were divided into a death subgroup and a survival subgroup according to their prognosis. The serum levels of three markers upon admission were compared between the two subgroups，and analysis of receiver operating characteristic（ROC）curve was performed to evaluate the predictive value of serum marker levels for prognosis in SAP patients. Results The BISAP and APACHE Ⅱ scores，as well as the levels of serum S100A6，S100A9，and S100A12，were significantly higher in the severe group than in the non-severe group upon admission（P<0.01）. Pearson correlation analysis showed that the serum levels of S100A6，S100A9，andS100A12 at admission were positively correlated with the APACHE Ⅱ score in the severe group，respectively（r=0.710，0.880，0.860，P<0.01，and the level of S100A6 was positively correlated with BISAP scores（r=0.260，P<0.05）. The serum levels of these three markers were significantly higher in the death subgroup compared to the survival subgroup upon admission（P<0.01）. ROC curve analysis indicated that the area under curve（AUC）for predicting mortality in SAP patients using serum S100A6，S100A9，and S100A12 levels upon admission were 0.870，0.904，and 0.915，respectively. Conclusion The serum levels of S100A6，S100A9，and S100A12 are significantly elevated in SAP patients at admission，closely correlated with the severity of the condition. The levels of these serum markers at admission has high predictive value for the prognosis of SAP patients.
文章编号： 中图分类号：R657.5+1 文献标志码：A
基金项目:江苏省研究型医院学会转化基金专项资助（SYHKJ-XF-2025-21）；南京医科大学第四附属医院院级课题（2024YJKT20）
附件
| 作者 | 单位 |
| 王秀娟 | 南京医科大学第四附属医院重症医学科,江苏 南京 210031 |
| 李萍 | 南京医科大学第四附属医院重症医学科,江苏 南京 210031 |
| 王硕 | 南京医科大学第四附属医院重症医学科,江苏 南京 210031 |
| 王玲 | 南京医科大学第四附属医院重症医学科,江苏 南京 210031 |
| 王巍 | 南京医科大学第四附属医院重症医学科,江苏 南京 210031 |
| Author Name | Affiliation |
| WANG Xiujuan，LI Ping，WANG Shuo，WANG Ling，WANG Wei | Intensive Care Unit,The Fourth Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210031,China |
引用文本：
王秀娟,李萍,王硕,等.三项血清S100钙结合蛋白水平对重症急性胰腺炎患者预后的诊断价值[J].中国临床研究,2026,39(1):103-106.
王秀娟,李萍,王硕,等.三项血清S100钙结合蛋白水平对重症急性胰腺炎患者预后的诊断价值[J].中国临床研究,2026,39(1):103-106.