Abstract:Objective To explore the application of C-reactive protein-albumin-lymphocyte（CALLY）index in patients with acute decompensated heart failure（ADHF）and its predictive value of prognosis. Methods A total of 1 267patients with ADHF who were admitted to the Nanjing Drum Tower Hospital，Nanjing University Medical School from September 2010 to December 2018 were retrospectively enrolled. The CALLY index was calculated as follows：（albumin× lymphocyte count）/（C-reactive protein × 10）. The patients were divided into three groups based on tertiles：T1（CALLY index <0.64），T2（0.64 ≤ CALLY index <2.05），and T3（CALLY index ≥ 2.05）. Baseline characteristics among the three groups were compared，and the incidences of all-cause death，cardiac death，and major adverse cardiovascular events（MACE）after 1 and 5 years were evaluated. A Cox proportional hazards model was established to analyze the predictive value of the CALLY index for the prognosis of ADHF，and the consistency index was used to test the predictive value of the model. Results During the 1-year and 5-year follow-up，there were 76 cases（6.0%）and161 cases（12.7%）of cardiac death，138 cases（10.9%）and 332 cases（26.2%）of all -cause death，as well as 426cases（33.6%）and 715 cases（56.4%）of MACE events，respectively. There were significant differences in the incidences of all-cause death，cardiac death，and MACE among the three groups，with the highest event rates in GroupT1（P<0.05）. After adjustment with three models，multivariate Cox regression analysis showed that the CALLY index was an independent predictor of all-cause death and cardiac death，respectively（P<0.05）. The consistency index test showed that the model incorporating the CALLY index was superior to the conventional model. Conclusion The CALLY index is associated with all-cause death and cardiac death in patients with ADHF，serving as an independent predictor for these outcomes，but it is not related to MACE events.