Abstract:Objective To analyze the maternal factors associated with adverse pregnancy outcomes in women undergoing in vitro fertilization-embryo transfer (IVF-ET). Methods A retrospective analysis was conducted on data from 1 336 pregnant women who received IVF-ET treatment at the Women's Hospital of Nanjing Medical University between January 2022 and December 2024. The differences in delivery mode, preterm birth, premature rupture of membranes, placental adhesion, perineal laceration, and neonatal hypoglycemia across factors such as age, pre-pregnancy body mass index (BMI), gestational hypertension, and gestational diabetes mellitus were compared. Binomial logistic regression analysis was used to evaluate the influencing factors of adverse pregnancy outcomes. Results Statistically significant differences were observed for age ≥35 years in terms of delivery mode, placental adhesion, and perineal laceration (P<0.05). Pre-pregnancy BMI showed statistically significant differences in delivery mode and perineal laceration (P<0.05). Gestational hypertension demonstrated statistically significant differences in delivery mode, preterm birth, and perineal laceration (P<0.05). Gestational diabetes mellitus showed a statistically significant difference in neonatal hypoglycemia (P<0.05). Age ≥35 years (OR=0.597, P=0.004) and pre-pregnancy BMI >23.9-<28.0 kg/m² (OR=0.406, P=0.001) were protective factors for vaginal delivery. Gestational hypertension was a risk factor for 35 years (OR=0.619, P=0.014) and pre-pregnancy BMI >23.9-<28.0 kg/m² (OR=0.455, P=0.005) were protective factors against perineal laceration. Gestational diabetes mellitus was a risk factor for neonatal hypoglycemia (OR=1.828, P=0.007). Conclusion IVF-ET pregnancy outcomes are influenced by age, BMI, and pregnancy complications.