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投稿时间：2025-09-02 网络发布日期：2025-12-25
投稿时间：2025-09-02 网络发布日期：2025-12-25
中文摘要: 目的 探讨在经皮冠脉介入术（PCI）治疗冠状动脉粥样硬化性心脏病（冠心病）后，采用全身免疫炎症指数（SII）、纤维蛋白原/白蛋白比值（FAR）及二者联合预测再次血运重建的临床应用价值。方法 采用回顾性队列研究方法，选取2019年7月至2020年6月江南大学附属医院心内科收治的接受PCI术的患者为研究对象，经随访共获得术后5年内于该院复查冠状动脉造影（CAG）的患者217例。根据CAG复查结果，将所纳入患者分为再次重建组（106例）和非重建组（111例）。比较两组临床资料，采用多因素二元logistic回归分析评估SII、FAR与PCI术后再次血运重建的关系，用受试者工作特征（ROC）曲线分析SII、FAR及二者联合对PCI术后再次血运重建的预测效能。结果 单因素分析显示，年龄、中性粒细胞计数、淋巴细胞计数、血小板计数、纤维蛋白原、白蛋白、血清肌酐、糖化血红蛋白、高密度脂蛋白胆固醇、SII、FAR、左室射血分数、单支病变、多支病变、支架内再狭窄与PCI术后再次血运重建有一定的相关性（P<0.05）。多因素二元logistic回归分析显示，在校正混杂因素后，SII（OR=1.002，95%CI:1.001~1.003，P=0.003）及FAR（OR=1.329，95%CI:1.072~1.646，P=0.009）是PCI术后再次血运重建的独立影响因素。ROC曲线分析显示，SII、FAR及二者联合预测PCI术后再次血运重建的曲线下面积（AUC）分别为0.707、0.693和0.733，以二者联合预测为高。结论 SII、FAR增高是PCI术后再次血运重建的独立风险因素，SII、FAR对PCI术后再次血运重建有较好的预测效能，二者联合预测效能更高。
Abstract:Objective To explore the clinical application value of systemic immune-inflammation index (SII), fibrinogen- to-albumin ratio (FAR), and their combination to predict re-revascularization after percutaneous coronary intervention (PCI) for coronary heart disease. Methods Using a retrospective cohort study method, patients who underwent PCI in the Department of Cardiology at Affiliated Hospital of Jiangnan University from July 2019 to June 2020 were selected as the study subjects. During follow-up, a total of 217 patients who had coronary angiography (CAG) re-examinations at this hospital within 5 years after operation were obtained. According to the results of the CAG re-examination, the patients were divided into the re-revascularization group (106 cases) and the non-revascularization group (111 cases). General data of the two groups were compared. Multivariate binary logistic regression analysis was used to evaluate the association of SII and FAR with re-revascularization after PCI, and receiver operating characteristic (ROC) curve was used to analyze the predictive efficacy of SII, FAR and their combination for re-revascularization after PCI. Results Univariate analysis showed that age, neutrophil count, lymphocyte count, platelet count, fibrinogen, albumin, serum creatinine, glycated hemoglobin, high-density lipoprotein cholesterol, SII, FAR, left ventricular ejection fraction, single-vessel disease, multi-vessel disease, and in-stent restenosis were significantly associated with re-revascularization after PCI (P<0.05). Multivariate binary logistic regression analysis revealed that after adjusting for confounding factors, SII (OR= 1.002, 95%CI: 1.001-1.003, P=0.003) and FAR (OR=1.329, 95%CI: 1.072-1.646, P=0.009) were independent predictors of re-revascularization after PCI. ROC curve analysis indicated that the area under the curve (AUC) for predicting re-revascularization after PCI was 0.707 for SII, 0.693 for FAR, and 0.733 for the combination of both, with the combined prediction being higher. Conclusion Elevated SII and FAR are independent risk factors for re-revascularization after PCI. Both SII and FAR have good predictive efficacy for re-revascularization after PCI, and their combined predictive efficacy is even higher.
keywords: Coronary artery disease Percutaneous coronary intervention Revascularization Repeat Systemic immune- inflammation index Fibrinogen-to-albumin ratio
文章编号： 中图分类号：R541.4 文献标志码：A
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引用文本：
李云飞,杨晓,王晓彦.全身免疫炎症指数及纤维蛋白原/白蛋白比值对经皮冠脉介入术后再次血运重建的预测效能[J].中国临床研究,2025,38(12):1908-1912，1917.
李云飞,杨晓,王晓彦.全身免疫炎症指数及纤维蛋白原/白蛋白比值对经皮冠脉介入术后再次血运重建的预测效能[J].中国临床研究,2025,38(12):1908-1912，1917.