Abstract:Objective To investigate the effects of a preemptive analgesia regimen with oxycodone hydrochloride on vital signs, analgesic quality, pain mediators, and inflammatory factor levels in patients undergoing tangential excision and skin grafting during the perioperative anesthesia management period. Methods A total of 1 200 patients undergoing tangential excision and skin grafting at 910th Hospital of PLA Joint Logistic Support Force from June 2021 to June 2024 were selected as the study subjects and randomly assigned to two groups. Ultimately, 837 patients were included in the analysis, with 420 cases in the observation group and 417 cases in the control group. Patients in the observation group received an intravenous injection of 0.1 mg/kg oxycodone hydrochloride injection 10 minutes before anesthesia induction, while patients in the control group received an intravenous injection of 10 mL normal saline. The perioperative vital signs [mean arterial pressure (MAP) and heart rate], analgesic quality [Visual Analog Scale (VAS) score], pain mediator indicators (norepinephrine, 5-hydroxytryptamine), and inflammatory factor levels [interleukin (IL) -6, tumor necrosis factor (TNF) -α, and cortisol] were compared between the two groups. The Quality of Recovery- 40 (QoR-40) scale was used to assess the quality of recovery 24 hours postoperatively, and the incidence of adverse reactions was recorded. Results Compared with the control group, patients in the observation group demonstrated better stability in MAP and heart rate during anesthesia induction and tracheal intubation (P<0.05). Within 24 hours postoperatively, the VAS scores, serum levels of norepinephrine, 5-hydroxytryptamine, IL-6, TNF-α, and cortisol in the observation group were significantly lower than those in the control group (P<0.05). The total score and all dimension scores of the QoR-40 in the observation group were significantly higher than those in the control group (P< 0.05). The total incidence of adverse reactions in the observation group was significantly lower than that in the control group [9.05% (38/420) vs 21.34% (89/417), χ²=24.58, P<0.01]. Conclusion Oxycodone hydrochloride preemptive analgesia regimen can improve perioperative analgesic quality in burn patients undergoing tangential excision and skin grafting, stabilize vital signs during operation, reduce the release of serum pain mediators and the occurrence of adverse reactions, and promote postoperative recovery.