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投稿时间:2025-01-15 网络发布日期:2025-10-20
投稿时间:2025-01-15 网络发布日期:2025-10-20
中文摘要: 腹部手术术后疼痛可造成患者精神、躯体双重创伤,直接影响患者预后转归。而术后有效镇痛可促进患者胃肠功能恢复,缩短患者痊愈进程。布比卡因脂质体是近年来临床采用脂质体技术制备的新型酰胺类局部麻醉药,单剂量注射可产生 72 h长效镇痛,是多模式镇痛的重要组成部分,其在全膝关节置换术、乳腺手术等多种外科手术术后镇痛中的应用价值已得到广泛证实。本文将从药理学特性、临床应用、安全性等方面综述布比卡因脂质体在腹部手术术后镇痛的应用效果。
Abstract:Postoperative pain after abdominal surgery can cause both mental and physical trauma which directly affect the prognosis of patients. Effective postoperative analgesia can promote the recovery of gastrointestinal function and shorten the recovery process of patients. Bupivacaine liposomes is a new type of amide local anaesthesia developed in recent years using liposome technology for clinical application. Single dose injection can produce long -lasting analgesia for 72 hours,which is an important part of multimodal analgesia. Its application value has been widely validated in postoperative analgesia after total knee replacement,breast surgery and other surgical procedures. The article reviews the effects of bupivacaine liposomes on postoperative analgesia after abdominal surgery from the aspects of pharmacological properties,clinical application and safety.
keywords: Abdominal surgery Postoperative analgesia Bupivacaine liposome Pharmacokinetics Pharmacodynamics
文章编号: 中图分类号:R614.1 文献标志码:A
基金项目:
附件
| 作者 | 单位 |
| 鲍蕾 | 1. 四川大学华西医院麻醉科,四川 成都 610000;2. 成都市第七人民医院麻醉科,四川 成都 610000 |
| 何雪梅 | 1. 四川大学华西医院麻醉科,四川 成都 610000 |
| 王儒蓉 | 1. 四川大学华西医院麻醉科,四川 成都 610000 |
| Author Name | Affiliation |
| BAO Lei*,HE Xuemei,WANG Rurong | *Department of Anesthesiology,West China Hospital,Sichuan University,Chengdu,Sichuan 610000,China |
引用文本:
鲍蕾,何雪梅,王儒蓉.布比卡因脂质体在腹部手术患者术后镇痛中应用的研究进展[J].中国临床研究,2025,38(10):1471-1474.
鲍蕾,何雪梅,王儒蓉.布比卡因脂质体在腹部手术患者术后镇痛中应用的研究进展[J].中国临床研究,2025,38(10):1471-1474.
