Abstract:Energy metabolism is closely related to the development of various diseases. With the increasing prevalence of diabetes year by year, diabetic kidney disease (DKD), as a common vascular complication of diabetes, is also on the rise. In the past, glomerular injury was considered as the main pathogenesis of DKD, but more and more evidence shows that renal tubular injury is an important factor that causes DKD. There is aberrant cellular energy metabolism in renal tubular injury in diabetes, suggesting that aberrant energy metabolism may play a potential role in the development and progression of renal tubular injury in diabetes. This article reviews the pathophysiological mechanism of aberrant energy metabolism in diabetic renal tubular injury in recent years.