Abstract:In recent years，the cardiotoxicity of antimicrobials has become a focus in the prevention and treatment of valvular heart disease（VHD）. Acute valve dysfunction is primarily associated with drug dosage or allergic reactions，while chronic valve disease is characterized by valve degeneration. The risk factors contributing to this type of damage are multiple，including advanced age，prosthetic valve replacement，and renal dysfunction. The underlying mechanisms involve disorders of collagen metabolism and increased cumulative drug toxicity. This article provides a comprehensive review of current research on the adverse effects of antimicrobials on cardiac valves，examining the impact of various antimicrobials from perspectives such as types of antimicrobials，injury mechanisms，clinical manifestations，and preventive measures. The goal is to offer an evidence-based foundation for balancing infection prevention and cardiac safety in clinical practice.