Abstract:Objective To explore the factors associated with achieving early objective response in patients with unresectable hepatitis B virus（HBV）-related liver cancer after three months of triple therapy，including transcatheter arterial chemoembolization（TACE），lenvatinib，and programmed death receptor- 1（PD-1）inhibitors. Methods The clinical data of triple therapy in the treatment of unresectable HBV-related liver cancer in Xiangyang Central Hospital from January 2020 to November 2023 were retrospectively analyzed. According to the modified response evaluation criteria in solid tumors（mRECIST），partial response and complete response were defined as objective response. Multivariate logistic regression analysis was performed to determine the independent factors influencing early objective response achievement after triple therapy. Results Data of 87 patients were obtained. Among them，50 patients with early objective response after triple therapy for unresectable HBV-related HCC were divided into the response group，and 37 patients without objective response were divided into the non-response group. Logistic regression analysis showed that extrahepatic metastasis（OR=0.264，95%CI：0.076-0.913），alpha-fetoprotein（AFP）>400 ng/mL（OR=0.330， 95%CI：0.118- 0.919），and HBV-DNA>1 000 IU/mL（OR=0.305，95%CI：0.103- 0.899）were independent risk factors for early objective response in patients with unresectable HBV - related HCC after triple therapy（P<0.05）.Conclusion Extrahepatic metastasis，AFP and HBV - DNA are independent factors of early objective response in patients with unresectable HBV-related liver cancer after triple therapy.