Abstract:The pathogenesis of primary constipation remains unclear，and the interaction between gut microbiota and bile acids may bean important mechanism underlying its occurrence. The abundant microorganisms in the gut play a key role in the biotransformation of bile acids ，while alterations in the bile acid pool reciprocally regulate the gut microbial community. This article focuses on elucidating the impact of gut microbiota，bile acids，and their interaction on primary constipation，aiming to provide new insights for its treatment.