Abstract:Objective To investigate the risk factors for residual pain after percutaneous vertebroplasty（PVP）in the treatment of osteoporotic vertebral compression fractures（OVCF）. Methods A total of 132 patients diagnosed with OVCF and undergoing PVP at Ma ,anshan People, s Hospital from August 2022 to August 2023 were selected. Based on the presence of residual pain postoperatively，the patients were divided into an observation group（with residual pain） and a control group（without residual pain）. The general data ，preoperative bone mineral density ，bone cement injection time ，amount of bone cement injected ，bone cement dispersion rate ，preoperative vertebral height compression，and patient anxiety status were compared between the two groups. Multivariate logistic regression analysis was used to evaluate the influence of various factors on residual pain after PVP in OVCF patients.Results Among the 132 OVCF patients，22（16.7%）experienced residual pain after PVP. Significant differences were observed between the two groups in preoperative bone mineral density ，bone cement injection time ，bone cement dispersion rate，preoperative vertebral height compression ，and HAMA scores （P<0.05）. Multivariate logistic regression analysis revealed that prolonged bone cement injection time（ OR=1.039，95%CI：1.011-1.068），low bone cement dispersion degree（ OR=0.841，95%CI：0.729-0.971），and high HAMA score（ OR=1.239，95%CI：1.070-1.435）were independent risk factors for residual pain after PVP in OVCF patients（P<0.05）. Conclusion Residual pain after PVP in OVCF patients is associated with bone cement injection time，bone cement dispersion degree，and patient anxiety status. Clinicians should pay closer attention to and take preventive measures when encountering these risk factors to reduce the incidence of residual pain and improve patient prognosis.