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中国临床研究:2025,38(7):988-992
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结直肠癌肝转移外科治疗
(北京大学肿瘤医院内蒙古医院 内蒙古医科大学附属肿瘤医院肝胆胰肿瘤外科,内蒙古 呼和浩特 010020)
Surgical management of liver metastases from colorectal cancer
(Department of Hepato?Biliary?Pancreatic Surgical Oncology,Peking University Cancer Hospital,Inner Mongolia Campus,Affiliated Cancer Hospital of Inner Mongolia Medical University,Hohhot,Inner Mongolia 010020,China)
摘要
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投稿时间:2025-03-03   网络发布日期:2025-07-21
中文摘要: 随着结直肠癌发病率的持续攀升,约50%的患者在病程中会出现肝转移。根据国际分期标准,结直肠癌肝转移(CRLM)已属晚期病变,其临床预后普遍不良。近年来,CRLM治疗体系呈现多维度发展态势,在治疗理念持续革新的背景下,基于外科手术的综合治疗方案已被证实可为患者带来显著生存获益。值得关注的是,靶向药物及免疫治疗等新型治疗手段的应用,不仅明显延长了晚期患者的总体生存期,同时使肝转移病灶的可切除率显著提升。在手术技术层面,术中超声导航、射频消融联合切除技术以及荧光腹腔镜引导下的精准肝切除等创新方法,已使手术安全性和精准度获得突破性提升。然而,目前CRLM在外科治疗领域仍存在诸多争议,包括手术指征的把握、多学科协作模式下的手术时机选择、不同局部治疗手段的适应证界定等关键问题尚未形成统一共识。本文通过对CRLM外科治疗进展进行总结和经验分享,以期为提升CRLM外科治疗水平提供实践参考。
Abstract:With the persistent rise in colorectal cancer incidence,approximately 50% of patients develop liver metastases during the disease course. According to international staging systems,colorectal cancer liver metastases(CRLM)are classified as advanced-stage malignancies,typically associated with poor clinical prognoses.In recent years,the CRLM treatment paradigm has undergone multidimensional evolution. Against the backdrop of continuously evolving therapeutic concepts,comprehensive treatment strategies centered on surgical intervention have demonstrated substantial survival benefits. Notably,the integration of novel therapies-including targeted agents and immunotherapy-has not only significantly extended overall survival in advanced cases but also markedly improved the resectability of hepatic metastatic lesions. From a technical perspective,innovations such as intraoperative ultrasound navigation,radiofrequency ablation combined with resection techniques,and fluorescence laparoscopy-guided precise hepatectomy have achieved breakthroughs in surgical safety and accuracy. Nevertheless,critical controversies persist in the surgical management of CRLM,particularly regarding the refinement of surgical indications,optimization of surgical timing within multidisciplinary frameworks,and evidence-based selection of local treatment modalities,all of which remain subjects of ongoing debate.This review synthesizes recent high-impact literature with our institutional expertise in CRLM management to summarize contemporary advancements and share practical insights,aiming to inform clinical decision-making and enhance surgical outcomes in CRLM treatment.
文章编号:     中图分类号:R445.1    文献标志码:A
基金项目:北京大学肿瘤医院内蒙古医院“青苗”人才计划(消化道肿瘤重点专科)(QM202311)
附件
引用文本:
吉九威,张勇刚,王宏伟.结直肠癌肝转移外科治疗[J].中国临床研究,2025,38(7):988-992.

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