Abstract:Tumor microenvironment plays an important role in cancer progression and treatment resistance，and its complexity stems from the dynamic roles of multiple cell types（tumor-associated fibroblasts，mesenchymal stem cells，tumor-associated macrophages，and natural killer cells，etc.）and metabolic factors（lipid metabolites，reactive oxygen species，etc.）. In this paper，the role of key components of the tumor microenvironment in colorectal cancer metastasis and the impact on treatment are systematically described，with a view to providing ideas and references for the treatment of colorectal cancer.