Abstract:Objective To observe the changes of coagulation function in patients with colorectal cancer (CRC) after laparoscopic surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC). Methods Sixty patients with CRC admitted to The People's Hospital of Kaizhou District, CQ from January to October 2023 were selected as the study subjects and randomly divided into study group and control group, with 30 cases in each group. The control group underwent laparoscopic surgery, while the study group underwent laparoscopic surgery combined with HIPEC (fluorouracil). The surgical conditions and changes in perioperative coagulation function indicators were observed and compared between two groups. Results There was no statistically significant difference between the study group and the control group in intraoperative blood loss ［（84.33±40.66）mL? vs （100.33±52.82）mL］, surgical time ［（174.77±31.29）min? vs （167.67±28.61）min］, anal exhaust time ［（3.17±0.79）d? vs （3.03±0.81）d］, and postoperative hospital stay ［（14.23±3.76）d? vs （14.70±5.34）d］ (P＞0.05). The levels of prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), and D-dimer (D-D) in the two groups showed significant fluctuations over time (P＜0.05), while there was no significant difference in the above indicators between the two groups (P＞0.05). There was no statistically significant difference in the total incidence of postoperative complications (20.00%? vs 13.33%, χ²=0.481, P=0.488) such as abdominal bleeding, deep vein thrombosis, intestinal obstruction, and anastomotic fistula between the two groups. Conclusion Although laparoscopic surgery leads to enhanced coagulation function and hypercoagulable blood in patients with CRC, the combination of postoperative HIPEC does not increase the risk of postoperative deep vein thrombosis, therefore, HIPEC technology is still safe and reliable.