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投稿时间：2022-05-27 网络发布日期：2022-09-20
投稿时间：2022-05-27 网络发布日期：2022-09-20
中文摘要: 宫颈癌是一种女性常见的恶性肿瘤,目前研究发现人半翼基因(hWAPL)仅在宫颈癌患者组织中表达明显增高, 部分研究也发现，hWAPL随着宫颈癌恶性程度的增高而表达上调。而在人乳头瘤病毒(HPV)相关E6和E7癌蛋白过表达的细胞中均能检测到hWAPL的高表达。而这些都说明hWAPL与HPV所致的宫颈癌有着密切的关系，这不仅揭示了HPV致癌的原因，也为宫颈癌的诊疗提供了新的方向。
Abstract:Cervical cancer is a common malignant tumor in women. At present, studies have found that the expression of human wings apart-like (hWAPL) is significantly increased only in the tissues of cervical cancer patients. Some studies have also found that the expression of hWAPL is up-regulated with the increase of the malignant degree of cervical cancer. High expression of hWAPL was detected in cells with overexpression of human papillomavirus (HPV)-related E6 and E7 oncoproteins. All these show that hWAPL is closely related to HPV induced cervical cancer, which not only reveals the cause of HPV carcinogenesis, but also provides a new direction for the diagnosis and treatment of cervical cancer.
文章编号： 中图分类号：R737.3 文献标志码：A
基金项目:
| Author Name | Affiliation |
| LIU Yang-jie* | *Xi'an Medical University, Xi'an, Shaanxi 710000, China |
| JIANG Xiang-yang | |
| LIU Wen-kang |
引用文本：
刘杨洁,姜向阳,刘文康.hWAPL蛋白表达与HPV感染在宫颈癌发生发展中的研究进展[J].中国临床研究,2022,35(9):1257-1260,1265.
刘杨洁,姜向阳,刘文康.hWAPL蛋白表达与HPV感染在宫颈癌发生发展中的研究进展[J].中国临床研究,2022,35(9):1257-1260,1265.