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中国临床研究:2022,35(6):840-843
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新型冠状病毒肺炎与肾素-血管紧张素系统相关研究进展
(南京中医药大学附属南京医院 南京市第二医院重症医学科, 江苏 南京 210003)
Novel coronavirus disease-2019 and renin-angiotensin system
(Department of Critical Medicine, Nanjing Second Hospital, Affiliated Nanjing Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210003, China)
摘要
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投稿时间:2021-11-24   网络发布日期:2022-06-20
中文摘要: 目前,世界爆发的新型冠状病毒肺炎(COVID-19)受到国内外的广泛关注。有研究显示,介导新型冠状病毒(2019-nCoV)跨物种传播受体与SARS冠状病毒(SARS-CoV)一致,均为血管紧张素转化酶-2(ACE2)。肾素-血管紧张素(RAS)系统是机体内关键的体液调节系统,在心血管功能稳态及电解质体液平衡调节中发挥着重要作用。在全国抗“疫”的形势下,2019-nCoV与RAS系统的相关研究受到临床医生的关注和重视。本文就当前关注的热点,包括COVID-19、ACE2、ACE抑制剂(ACEI)/血管紧张素受体阻滞剂(ARB) 类药物及其相关性的研究进展作一综述。
Abstract:Nowadays, the outbreak of the novel coronavirus disease-2019 (COVID-19) in the world has attracted widespread attention at home and abroad. Studies have shown that the receptor that mediates cross-species transmission of 2019-new coronavirus (2019-nCoV) is consistent with SARS-CoV, both of which are angiotensin converting enzyme-2 (ACE2). The renin-angiotensin system (RAS) is a key humoral regulation system in the body and plays an important role in the regulation of cardiovascular function homeostasis and water-electrolyte balance. Under the situation of national anti-epidemic, the research on 2019-nCoV and RAS system has attracted attention from clinicians. This article will review the current hot topics, including COVID-19, ACE2, ACE inhibitor (ACEI)/angiotensin receptor blocker (ARB) drugs and their related research progress.
文章编号:     中图分类号:R511    文献标志码:A
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引用文本:
卢虎,郑义山.新型冠状病毒肺炎与肾素-血管紧张素系统相关研究进展[J].中国临床研究,2022,35(6):840-843.

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