Abstract:Objecitve To compare the therapeutic effects of sacubitril/valsartan and perindopril on cardiac dysfunction after acute myocardial infarction. Methods From March to October 2018, 90 patients with cardiac dysfunction after acute anterior wall myocardial infarction were treated in Nanjing First Hospital and were randomly divided into perindopril group and sacubitril/valsartan group(n=45, each).On the basis of routine drug treatment, perindopril 8 mg per day was given in perindopril group, while sacubitril/valsartan 50 mg twice per day was given in sacubitril/valsartan group.The changes of various cardiac function indexes were compared before and after treatment between two groups. Results With the time going on, left ventricular ejection fraction(LVEF) and left ventricular end diastolic diameter(LVDD) were improved, and the level of N-terminal fragment of B-type natriuretic peptide (NT-proBNP) significantly decreased treated by perindopril and sacubitril/valsartan (P<0.05).At the 7 days, 3 months, 6 months and 1 year after treatment, NT-proBNP level and LVDD decreased, and LVEF increased in sacubitril/valsartan group compared with perindopril group (all P<0.01). Conclusion Compared with perindopril, Sacubitril/valsartan is shown to be more effective in improving the clinical outcome and reducing the risk of hospitalization in the patients with cardiac insufficiency after acute myocardial infarction.